期刊
VIRUSES-BASEL
卷 3, 期 6, 页码 829-857出版社
MDPI
DOI: 10.3390/v3060829
关键词
HTLV-1; Tax; retrovirus; signal transduction; NF-kappa B; nuclear bodies; intracellular trafficking; posttranslational modifications; leukemia
类别
资金
- Belgian Fonds National de la Recherche Medicale
- FNRS-Televie
- Internationale Brachet Stiftung
The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据