期刊
VIRUSES-BASEL
卷 3, 期 8, 页码 1332-1341出版社
MDPI AG
DOI: 10.3390/v3081332
关键词
lipid metabolism; lipophagy; lipid droplet; beta-oxidation
类别
资金
- Region V Great Lakes RCE (NIH) [1-U54-AI-057153]
- NIH [T32 AI065382-01]
- William Rainey Harper Fellowship
Several independent groups have published that autophagy is required for optimal RNA replication of dengue virus (DENV). Initially, it was postulated that autophagosomes might play a structural role in replication complex formation. However, cryo-EM tomography of DENV replication complexes showed that DENV replicates on endoplasmic reticulum (ER) cisternae invaginations and not on classical autophagosomes. Recently, it was reported that autophagy plays an indirect role in DENV replication by modulating cellular lipid metabolism. DENV-induced autophagosomes deplete cellular triglycerides that are stored in lipid droplets, leading to increased beta-oxidation and energy production. This is the first example of a virus triggering autophagy to modulate cellular physiology. In this review, we summarize these data and discuss new questions and implications for autophagy during DENV replication.
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