4.6 Review

Macrophages and Cell-Cell Spread of HIV-1

期刊

VIRUSES-BASEL
卷 2, 期 8, 页码 1603-1620

出版社

MDPI
DOI: 10.3390/v2081603

关键词

HIV-1; macrophage; synapse; transmission

类别

资金

  1. NIH, National Cancer Institute, Center for Cancer Research
  2. Intramural AIDS Targeted Antiviral Program

向作者/读者索取更多资源

Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据