期刊
VIRUSES-BASEL
卷 2, 期 10, 页码 2226-2234出版社
MDPI AG
DOI: 10.3390/v2102226
关键词
HIV-1; Tat; transcription; P-TEFb; retroviruses
类别
资金
- NIH [K99/R00 A112185, RO1 AI29135, P50 GM082250]
HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat: P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
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