期刊
VIRUSES-BASEL
卷 2, 期 6, 页码 1261-1278出版社
MDPI AG
DOI: 10.3390/v2061261
关键词
HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion
类别
资金
- Medical Research Council [G0800312]
- Medical Research Council [G0800312] Funding Source: researchfish
- MRC [G0800312] Funding Source: UKRI
Cell-to-cell spread of HIV-1 between CD4(+) T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.
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