4.6 Review

HIV-1 Entry, Inhibitors, and Resistance

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Maraviroc for previously treated patients with R5 HIV-1 infection

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Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

Tongqing Zhou et al.

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Functional impact of HIV coreceptor-binding site mutations

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CCR5 deficiency increases risk of symptomatic West Nile virus infection

WG Glass et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

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Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

RS Veazey et al.

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Structure of a V3-containing HIV-1 gp120 core

CC Huang et al.

SCIENCE (2005)

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V3: HIV's switch-hitter

O Hartley et al.

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Identification of amino acid residues crucial for chemokine receptor dimerization

P Hernanz-Falcón et al.

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Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America

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Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

JD Reeves et al.

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G protein-coupled receptor allosterism and complexing

A Christopoulos et al.

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Association of chemokine-mediated block to HIV entry with coreceptor internalization

SM Brandt et al.

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HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

A Trkola et al.

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SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

JM Strizki et al.

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Aminooxypentane addition to the chemokine macrophage inflammatory Protein-1αP increases receptor affinities and HIV inhibition

JR Townson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Endocytosis and recycling of the HIV coreceptor CCR5

N Signoret et al.

JOURNAL OF CELL BIOLOGY (2000)

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Maturation of HIV envelope glycoprotein precursors by cellular endoproteases

M Moulard et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON BIOMEMBRANES (2000)

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Energetics of the HIV gp120-CD4 binding reaction

DG Myszka et al.

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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

T Dragic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)