期刊
VIRUSES-BASEL
卷 2, 期 8, 页码 1766-1781出版社
MDPI
DOI: 10.3390/v2081766
关键词
influenza virus; neuraminidase inhibitors; sialic acid; RNA polymerase
类别
资金
- National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN266200600015C]
- [U01AI070281]
While vaccines are the primary public health response to seasonal and pandemic flu, short of a universal vaccine there are inherent limitations to this approach. Antiviral drugs provide valuable alternative options for treatment and prophylaxis of influenza. Here, we will review drugs and drug candidates against influenza with an emphasis on the recent progress of a host-targeting entry-blocker drug candidate, DAS181, a sialidase fusion protein.
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