Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population

Our results showed that, at the same BMI level, Uygurs have greaterWHR values, abdominal visceral fat content, and diabetes risks than Kazaks. In addition, values of HDL-C in Uygur subjects were lower than those in Kazak subjects, and values of creatinine, uric acid, diastolic bloodpressure, bloodglucose, and fructosamine in Uygurmale subjects were lower than those in Kazakmale subjects. In contrast, systolic blood pressure values in Uygur subjects were greater than those in Kazak subjects, and blood glucose values were greater in Uygur female subjects than in Kazak female subjects. Additionally, in Uygurs, visceral adipose tissue expression levels of TBX1 and TCF21 were greater in obesity group than in normal and T2DM groups and lower in T2DM group than in normal group (P < 0.01). The visceral adipose tissue expression levels of APN in normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels of TNF-alpha and MCP-1 in normal group were lower than those in obesity and T2DMgroups (P < 0.01). In conclusion, T2DMin Uygurs was mainly associated with not only distribution of adipose tissue in body, but also change in metabolic activity and adipocytokines secretion of adipose tissue.