期刊
YONSEI MEDICAL JOURNAL
卷 55, 期 5, 页码 1165-1176出版社
YONSEI UNIV COLL MEDICINE
DOI: 10.3349/ymj.2014.55.5.1165
关键词
HMGB1; DAMP; inflammation; innate immunity
资金
- National Research Foundation of Korea (NRF) - Korea government (MEST) [2011-0017611, 2014R1A4A 1008625]
- National Research Foundation of Korea [2011-0017611, 2014R1A4A1008625] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
With growing accounts of inflammatory diseases such as sepsis, greater understanding the immune system and the mechanisms of cellular immunity have become primary objectives in immunology studies. High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is implicated in various aspects of the innate immune system as a damage-associated molecular pattern molecule and a late mediator of inflammation, as well as in principal cellular processes, such as autophagy and apoptosis. FIIVIGB1 functions in the nucleus as a DNA chaperone; however, it exhibits cytokine-like activity when secreted by injurious or infectious stimuli. Extracellular HMGB1 acts through specific receptors to promote activation of the NF-kappa B signaling pathway, leading to production of cytokines and chemokines. These findings further implicate BMGB1 in lethal inflammatory diseases as a crucial regulator of inflammatory, injurious, and infectious responses. In this paper, we summarize the role of HMGB1 in inflammatory and non-inflammatory states and assess potential therapeutic approaches targeting HMGB1 in inflammatory diseases.
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