期刊
YEAST
卷 29, 期 11, 页码 459-466出版社
WILEY
DOI: 10.1002/yea.2925
关键词
Candida; candidiasis; histatins; albumin; microscopy; salivary pellicle
资金
- Canadian Institutes of Health Research (CIHR) [106657, 97577, 113166]
- NSERC [371813]
- National Counsel of Technological and Scientific Development, Brazil (CNPq) [201265/2010-9]
The limited number of treatments for oral candidiasis resulted in the emergence of azole-resistant Candida albicans strains, thus enforcing the need for novel antifungal treatments. Although histatin 5 (H5) demonstrates antifungal activity, its inhibitory effect when adhered to hydroxyapatite and Polymetylmethacrylate (PMMA) surfaces, resembling conditions of the in vivo pellicle, remains unexplored. The objective of this in vitro study was to determine whether surface-adhered H5 inhibits the colonization of C. albicans on hydroxyapatite and/or PMMA. The C. albicans assay involved developing a mono-protein pellicle (either H5 or albumin) on hydroxyapatite and PMMA discs, introducing C. albicans and counting the number of adhered cells, throughout time, using scanning electron microscopy. A negative binomial statistical model and the TukeyKramer test were used for statistical analysis, with p?
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据