期刊
YEAST
卷 25, 期 8, 页码 537-548出版社
WILEY
DOI: 10.1002/yea.1603
关键词
pol alpha; heterochromatin; subtelomere; fission yeast; recombination
资金
- Council of Scientific and Industrial Research (CSIR), India
- CSIR, India.
Telomere length is regulated by a complex interplay of several factors, including telomerase, telomere-binding proteins, DNA replication machinery and recombination. In yeast, DNA polymerase alpha is required for de novo synthesis of telomeres from broken ends of DNA, and it also suppresses the elongation of normal telomeric repeats. Heterochromatin proteins Clr1-Clr4 and Swi6 and DNA pol alpha organize heterochromatin structure at mating type, centromere, rDNA and telomere regions that are refractory to transcription and recombination in Schizosaccharomyces pombe. Here, we have addressed the role of heterochromatin structure in regulating the integrity and organization of telomeric regions. Here, we show that subtelomeric duplication and rearrangements occur in pol alpha and heterochromatin mutants and find that sonic of the putative duplication events are dependent on the Rad50 pathway. Thus, our study shows a role of heterochromatin in maintaining the integrity of the subtelomeric regions by suppressing their recombination in Sz. pombe. Copyright (c) 2008 John Wiley & Sons, Ltd.
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