期刊
JOURNAL OF CANCER
卷 6, 期 9, 页码 877-882出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.11735
关键词
Argonaute-2; carcinomas; microRNAs; angiogenesis
类别
资金
- National Science Funds for general project [81001013]
- Creative Research Groups [81221061]
- Chinese Key Project for Infectious Diseases [2012ZX0002-014-005, 2013ZX10002-010-007]
- Military Youth Project [13QNP101]
- State Project For Essential Drug Research and Development [2013ZX09102-060]
AGO2 (Argonaute 2, EIF2C2) is the only member in AGO family with catalytic activity and of extreme importance during small RNAs guided gene silencing processes. The structural investigations have provided insights into details and functional mechanisms of the four major domains within AGO2. As a multifunction player, AGO2 has been revealed involved in tumorgenesis through miRNAs-dependent or independent ways. And nowadays, AGO2 has also been more importantly found ectopically over-expressed in carcinomas and closely associated with aspects of cancers in means of interacting with well-known tumor factors. Here, we provide a review on structural insights, functional mechanisms, novel roles and relationship with carcinomas of AGO2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据