期刊
XENOBIOTICA
卷 41, 期 8, 页码 735-742出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/00498254.2011.573015
关键词
Imipramine; skin; Straticell; MALDI-MS imaging
资金
- Cancer Research, UK
In order to assess the potential of matrix-assisted laser desorption mass spectrometry imaging for the examination of artificial skin models, the absorption of the tricyclic antidepressant imipramine into Straticell-RHE-EPI/001 an artificial model of the human epidermis has been studied. The presence of imipramine could be clearly discerned in treated samples by imaging the distribution of the protonated molecule at m/z 281.18 in samples taken 2 and 8 h after treatment. No clear evidence of biotransformation of imipramine in the artificial epidermal model was detected, although some signals that could potentially be assigned to the desmethyl metabolite were detected. Further work is required in order to investigate the reasons for the apparent low levels of metabolites detected.
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