期刊
XENOBIOTICA
卷 39, 期 3, 页码 249-254出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00498250802687657
关键词
Schisandra chinensis extract; Ginkgo biloba extract; talinolol; p-glycoprotein; inhibition; herb-drug interaction; pharmacokinetics
资金
- National Natural Science Foundation of China [30528026, 30300428, 30672497, 30500623, 30572225]
- China Medical Board of New York [01-755]
- Hunan Health Research Foundation of Traditional Chinese Medicine [204041]
The authors investigated the effect of herbal medicine Schisandra chinensis extract (SchE) and Ginkgo biloba extract (GBE) on the oral pharmacokinetics of P-glycoprotein substrate talinolol in humans. Twelve healthy male volunteers took a single 100-mg oral dose of talinolol either alone or after pretreatment with 300 mg SchE twice daily or with 120 mg GBE three times daily for 14 days. On day 14, a single 100-mg oral dose of talinolol was administered. Plasma concentrations of talinolol from zero to 24 h were measured by high-performance liquid chromatography. SchE increased the area under the curve (AUC)0-24 of talinolol by 47% (90% confidence interval (CI), 18-84%; p = 0.010), and GBE by 21% (90% CI = 11-32%; p = 0.002). The Cmax of talinolol increased by 51% (90% CI = 21-89%; p = 0.007) with SchE treatment and by 33% (90% CI = 18-51%; p = 0.002) with GBE treatment, respectively. The t1/2 of talinolol increased by 7% (90% CI = -4% to 19%; p = 0.320) with SchE treatment and by 11% (90% CI = -12% to 38%; p = 0.436) with GBE treatment, respectively. The results suggest that both SchE and GBE significantly inhibited P-glycoprotein in humans. Patients receiving either SchE or GBE may require dose adjustments when treated with drugs primarily transported by P-glycoprotein.
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