Impaired cutaneous wound healing in transforming growth factor-ß inducible early gene1 knockout mice

Transforming growth factor-beta inducible early gene (TIEG) is induced by transforming growth factor-beta (TGF-beta) and acts as the primary response gene in the TGF-beta/Smad pathway. TGF-beta is a multifunctional growth factor that affects dermal wound healing; however, the mechanism of how TGF-beta affects wound healing is still not well understood because of the complexity of its function and signaling pathways. We hypothesize that TIEG may play a role in dermal wound healing, with involvement in wound closure, contraction, and reepithelialization. In this study, we have shown that TIEG1 knockout (TIEG1/) mice have a delay in wound closure related to an impairment in wound contraction, granulation tissue formation, collagen synthesis, and reepithelialization. We also found that Smad7 was increased in the wounds and appeared to play a role in this wound healing model in TIEG1/ mice.