期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 20, 期 38, 页码 13741-13755出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i38.13741
关键词
Gastric cancer; Molecular targeting therapy; Human epidermal growth factor receptor 2 protein; Vascular endothelial growth factors/Vascular endothelial growth factor receptor pathway; Epidermal growth factors pathway
Trastuzumab that targets human epidermal growth factor receptor 2 (HER2) protein is the only approved molecular targeting agent for treating gastric cancer in Japan and the outcomes have been favorable. However, trastuzumab is effective for only 10% to 20% of the population with gastric cancer that expresses HER2 protein. Molecular targeting therapy with bevacizumab against vascular endothelial growth factors (VEGF) and with cetuximab and panitumumab against the epidermal growth factors pathway that have been approved for treating colorectal cancer are not considered effective for treating gastric cancer according to several clinical trials. However, ramucirumab that targets VEGF receptor-2 prolonged overall survival in a large phase. clinical trial and it might be an effective molecular targeting therapy for gastric cancer. The significance of molecular targeting therapy for gastric cancer remains controversial. A large-scale randomized clinical trial of novel molecular targeting agents with which to treat gastric cancer is needed. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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