期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 20, 期 18, 页码 5411-5419出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i18.5411
关键词
Non-coding RNA; MicroRNA; Piwi-interacting RNA; Long non-coding RNA; Small interfering RNA; Gastric cancer
资金
- National Natural Science Foundation of China [81171660]
- Zhejiang Provincial Natural Science Foundation of China [Y14C060003]
- Natural Science Foundation of Ningbo [2012A610207]
- Scientific Innovation Team Project of Ningbo [2011B82014]
- Project of Key Disciplines in Ningbo [XKL11D2127, XKL11D2128]
- Foundation of Zhejiang Provincial Key Laboratory of Pathophysiology [201301]
- K.C. Wong Magna Fund in Ningbo University
Non-coding RNAs (ncRNAs) play key roles in development, proliferation, differentiation and apoptosis. Altered ncRNA expression is associated with gastric cancer occurrence, invasion, and metastasis. Moreover, aberrant expression of microRNAs (miRNAs) is significantly related to gastric cancer tumor stage, size, differentiation and metastasis. MiRNAs interrupt cellular signaling pathways, inhibit the activity of tumor suppressor genes, and affect the cell cycle in gastric cancer cells. Some miRNAs, including miR-21, miR-106a and miR-421, could be potential markers for the diagnosis of gastric cancer. Long non-coding RNAs (IncRNAs), a new research hotspot among cancer-associated ncRNAs, play important roles in epigenetic, transcriptional and post-transcriptional regulation. Several gastric cancer-associated IncRNAs, such as CCAT1, GACAT1, H19, and SUMO1P3, have been explored. In addition, Piwi-interacting RNAs, another type of small ncRNA that is recognized by gastroenterologists, are involved in gastric carcinogenesis, and piR-651/823 represents an efficient diagnostic biomarker of gastric cancer that can be detected in the blood and gastric juice. Small interfering RNAs also function in post-transcriptional regulation in gastric cancer and might be useful in gastric cancer treatment. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据