期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 20, 期 20, 页码 6055-6072出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i20.6055
关键词
Colorectal cancer; Developing countries; Environment; Diet; Nuclear receptors; Gut microbiota
资金
- Institutional NRSA, clinical oncology research training program [T32 CA079447]
- Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan
- Office for the Associazione Italiana per la Ricerca sul Internationalization, G. d'Annunzio University, Chieti
- Carichieti Foundation, Chieti
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), Rome, Italy
- Fondazione Umberto Veronesi, Milan, Italy
- MRC [5PT57]
- MRC [MC_UP_A090_1006] Funding Source: UKRI
- Medical Research Council [MC_UP_A090_1006] Funding Source: researchfish
Colorectal cancer (CRC) is one of the leading causes of cancer and cancer-related mortality worldwide. The disease has been traditionally a major health problem in industrial countries, however the CRC rates are increasing in the developing countries that are undergoing economic growth. Several environmental risk factors, mainly changes in diet and life style, have been suggested to underlie the rise of CRC in these populations. Diet and lifestyle impinge on nuclear receptors, on the intestinal microbiota and on crucial molecular pathways that are implicated in intestinal carcinogenesis. In this respect, the epidemiological transition in several regions of the world offers a unique opportunity to better understand CRC carcinogenesis by studying the disease phenotypes and their environmental and molecular associations in different populations. The data from these studies may have important implications for the global prevention and treatment of CRC. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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