期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 20, 期 35, 页码 12493-12500出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i35.12493
关键词
Cancer; Colorectal; Carcinomatosis; Peritoneal; hyperthermic intraperitoneal chemotherapy; Intraperitoneal chemotherapy; Cytoreductive surgery; Mechanism
资金
- NIH [R01CA160688, T32CA085159-10]
Peritoneal carcinomatosis (PC), the dissemination of cancer cells throughout the lining of the abdominal cavity, is the second most common presentation of colon cancer distant metastasis. Despite remarkable advances in cytotoxic chemotherapy and targeted therapy for colon cancer over the last 15 years, it has been repeatedly shown that these therapies remain ineffective for colon cancer PC. Recently, there has been a rapid accumulation of reports that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) prolongs the life of colon cancer PC patients. Here, we will review the clinical presentation, the mechanisms of disease progression, and current treatment options for colon cancer PC, with a focus on the benefits and limitations of CRS-HIPEC. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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