期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 20, 期 26, 页码 8458-8470出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i26.8458
关键词
Pancreatic adenocarcinoma; c-Met; Chemoresistance; Receptor tyrosine kinase
Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States. The majority of patients are candidates only for palliative chemotherapy, which has proven largely ineffective in halting tumor progression. One proposed mechanism of chemoresistance involves signaling via the mesenchymal-epithelial transition factor protein (MET), a previously established pathway critical to cell proliferation and migration. Here, we review the literature to characterize the role of MET in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of MET as a therapeutic target in pancreatic cancer. In this review, we characterize the role of c-Met in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of c-Met as a therapeutic target in pancreatic cancer. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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