期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 18, 期 11, 页码 1249-1256出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v18.i11.1249
关键词
CC chemokine; Chemokine ligand 7; Chemokine ligand 21; Gastric cancer; Lymph node metastasis; Poor prognosis
资金
- National Science Council [NSC 98-2314-B-238-001]
- Vanung University, Taiwan [VIT-98-CM-01]
AIM: To investigate how a complex network of CC chemokine ligands (CCLs) and their receptors influence the progression of tumor and metastasis. METHODS: In the present study, we used immunohistochemistry to examine the expression of CCL7, CCL8 and CCL21 in 194 gastric cancer samples and adjacent normal tissues. We analyzed their correlation with tumor metastasis, clinicopathologic parameters and clinical outcome. RESULTS: We found that the higher expression of CCL7 and CCL21 in cancer tissues than in normal tissues was significantly correlated with advanced depth of wall invasion, lymph node metastasis and higher tumor node metastasis stage. Moreover, Kaplan-Meier survival analysis revealed that CCL7 and CCL21 overexpression in cancer tissues was correlated with poor prognosis. CONCLUSION: These results suggest that overexpression of these two CC chemokine ligands is associated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer. (C) 2012 Baishideng. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据