期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 18, 期 23, 页码 2995-3003出版社
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v18.i23.2995
关键词
Hepatocellular carcinoma; Metastasis-associated in colon cancer 1; c-Met; Prognostic factor; Recurrence
资金
- Key Scientific and Technological Research Foundation of the National Special-purpose Program [2008ZX10002-018]
- Capital Medical Development and Research in Beijing, China [2007-1021, 2009-2041]
AIM: To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: A retrospective study admitted three hundred fifty-four patients with HBV-related HCC. The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining. Prognostic factors influencing survival, metastasis and recurrence were assessed. RESULTS: Intratumoral MACC1 level was found to be associated with HCC disease progression. Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression, as compared to those with low intratumoral MACC1 levels (TFS: 34 mo vs 48.0 mo, P < 0.001; OS: 40 mo vs 48 mo, P < 0.01). Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P < 0.001). CONCLUSION: High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC. MACC1 may serve as a prognostic biomarker for postoperative HCC. (C) 2012 Baishideng. All rights reserved.
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