期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 17, 期 40, 页码 4470-4478出版社
BAISHIDENG PUBL GRP CO LTD
DOI: 10.3748/wjg.v17.i40.4470
关键词
Fascin; Invasiveness; Motility; Pancreatic cancer
资金
- Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences
- Ministry of Education of China [20060023013]
- National Nature Science Foundation of China [30471970, 30973470]
- National Science and Technology Support Project of China [2006BAI02A14]
- Health Ministry of China [200802011]
- National Data Sharing Project in Human Health [2005DKA32403]
- Roche Company
AIM: To explore the role of actin-bundling protein, fascin during the progression of pancreatic cancer. METHODS: The plasmid expressing human fascin-1 was stably transfected into the pancreatic cancer cell line MIA PaCa-2. The proliferation, cell cycle, motility, scattering, invasiveness and organization of the actin filament system in fascin-transfected MIA PaCa-2 cells and control non-transfected cells were determined. RESULTS: Heterogeneous overexpression of fascin markedly enhanced the motility, scattering, and invasiveness of MIA PaCa-2 cells. However, overexpression of fascin had minimal effect on MIA PaCa-2 cell proliferation and cell cycle. In addition, cell morphology and organization of the actin filament system were distinctly altered in fascin overexpressed cells. When transplanted into BALB/c-nu mice, fascin-transfected pancreatic cancer cells developed solid tumors at a slightly slower rate, but these tumors displayed more aggressive behavior in comparison with control tumors. CONCLUSION: Fascin promotes pancreatic cancer cell migration, invasion and scattering, thus contributes to the aggressive behavior of pancreatic cancer cells. (C) 2011 Baishideng. All rights reserved.
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