期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 17, 期 13, 页码 1710-1717出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v17.i13.1710
关键词
Gastric cancer; Gene expression profiling; Survival markers; Prognosis; Ribosomal proteins
资金
- National 863 Program [SQ2009AA02-XK1482570, 2006AA02A402]
- Beijing Municipal Committee of Science and Technology [D0905001040631]
- Beijing Capital Development Foundation of Health Bureau [2007-2051]
AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis. METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation. RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a low- and a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis. CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. (C) 2011 Baishideng. All rights reserved.
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