期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 16, 期 32, 页码 4003-4012出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v16.i32.4003
关键词
Colorectal neoplasms; Angiogenesis; Lymphangiogenesis; Lymphatic vessels; Lymphatic metastasis; Vascular endothelial growth factor; Monoclonal antibody D2-40; Therapy-related neoplasms; Biomarkers
资金
- SUMITOMO Life Social Welfare Services Foundation
- Virginia Commonwealth University [K12HD055881]
- Cure Career Catalyst Research Grant [KG090510]
Lymph node metastasis is the hallmark of colon cancer progression, and is considered one of the most important prognostic factors. Recently, there has been growing evidence that tumor lymphangiogenesis (formation of new lymphatic vessels) plays an important role in this process. Here, we review the latest findings of the role of lymphangiogenesis in colorectal cancer progression, and discuss its clinical application as a biomarker and target for new therapy. Understanding the molecular pathways that regulate lymphangiogenesis is mandatory to pave the way for the development of new therapies for cancer. In the future, tailored treatments consisting of combinations of chemotherapy, other targeted therapies, and anti-lymphangiogenesis agents will hopefully improve patient outcomes. This progression to the clinic must be guided by new avenues of research, such as the identification of biomarkers that predict response to treatment. (C) 2010 Baishideng. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据