期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 16, 期 29, 页码 3603-3615出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v16.i29.3603
关键词
Hepatocellular carcinoma; Etiology; Non-alcoholic; steatohepatitis; Obesity; Diabetes; Alcohol; Tobacco; Oral contraceptive
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and represents an international public health concern as one of the most deadly cancers worldwide. The main etiology of HCC is chronic infection with hepatitis B and hepatitis C viruses. However, there are other important factors that contribute to the international burden of HCC. Among these are obesity, diabetes, non-alcoholic steatohepatitis and dietary exposures. Emerging evidence suggests that the etiology of many cases of HCC is in fact multifactorial, encompassing infectious etiologies, comorbid conditions and environmental exposures. Clarification of relevant non-viral causes of HCC will aid in preventative efforts to curb the rising incidence of this disease. (C) 2010 Baishideng. All rights reserved.
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