期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 15, 期 4, 页码 417-422出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.417
关键词
Mycobacterium avium subspecies paratuberculosis; Crohn's diasease; Inflammatory bowel disease
资金
- Fundacion de Investigacion Medica Mutua Madrilena
The hypothesis postulating that Mycobacterium avium paratuberculosis (MAP) is the cause of Crohn's disease (CD) has been circulating for many years. Advances in molecular techniques, such as polymerase chain reaction and culture methods, have enabled researchers to demonstrate that there is an association between MAP and CID. Recently, genome-wide association studies have identified novel susceptibility genes for CD, which are critical for generation of an adaptive immune response that is protective against intracellular pathogens, including M. tuberculosis infection. However, the role of MAP as a cause of CD suffered a setback with the report that administration of antimycobacterial therapy failed to lead to a sustained response in CD patients. Accordingly, this review sought neither to confirm nor refute this, but instead to survey recent literature on the role of MAP in CD. (C) 2009 The WJG Press and Baishideng. All rights reserved.
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