期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 15, 期 13, 页码 1613-1619出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.1613
关键词
Alcoholic hepatitis; Pentoxifylline; Prednisolone; Maddrey discriminant function score; Model for end-stage liver disease score; Glasgow alcoholic hepatitis score
AIM: To compare the efficacy of pentoxifylline and prednisolone in the treatment of severe alcoholic hepatitis, and to evaluate the role of different liver function scores in predicting prognosis. METHODS: Sixty-eight patients with severe alcoholic hepatitis (Maddrey score >= 32) received pentoxifylline (n = 34, group I) or prednisolone (n = 34, group E) for 28 d in a randomized double-blind controlled study, and subsequently in an open study (with a tapering dose of prednisolone) for a total of 3 mo, and were followed up over a period of 12 mo. RESULTS: Twelve patients in group H died at the end of 3 mo in contrast to five patients in group I. The probability of dying at the end of 3 mo was higher in group 11 as compared to group 1 (35.29% vs 14.71%, P = 0.04; log rank test). Six patients in group R developed hepatorenal syndrome as compared to none in group I. Pentoxifylline was associated with a significantly lower model for end-stage liver disease (MELD) score at the end of 28 d of therapy (15.53 +/- 3.63 vs 17.78 +/- 4.56, P = 0.04). Higher baseline Maddrey score was associated with increased mortality. CONCLUSION: Reduced mortality improved risk-benefit profile and renoprotective effects of pentoxifylline compared with prednisolone suggest that pentoxifylline is superior to prednisolone for treatment of severe alcoholic hepatitis. (C) 2009 The WJG Press and Baishideng. All rights reserved.
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