期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 14, 期 40, 页码 6237-6243出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.14.6237
关键词
Probiotic; Sifidobacterium lactis DN-173010; Fermented milk; Constipation; Stool frequency; Stool consistency
AIM: To investigate the effect of a fermented milk containing Bifidobacterium lactis DN-173010 and yogurt strains (BIO (R)) on adult women with constipation in Beijing. METHODS: A total of 135 adult females with constipation were randomly allocated to consume for 2 wk either 100 g of the test fermented milk or 100 g of an acidified milk containing non-living bacteria (control). Stool frequency, defecation condition scores, stool consistency and food intake were recorded at baseline and after 1 and 2 wk in an intention-to-treat population of 126 subjects. In parallel, safety evaluation parameters were performed. RESULTS: At baseline, no differences were found between groups. Following consumption of test product, stool frequency was significantly increased after 1 wk (3.5 +/- 1.5 v5 2.4 +/- 0.6, P < 0.01) and 2 wk (4.1 +/- 1.7 v5 2.4 +/- 0.6, P < 0.01), vs baseline. Similarly, after 1 and 2 wk, of test product consumption, defecation condition (1.1 +/- 0.9 vs 1.9 +/- 1.2, P < 0.01 and 0.8 +/- 1.0 vs 1.9 +/- 1.2, P < 0.01, respectively) and stool consistency (1.0 +/- 0.8 vs 1.5 +/- 1.1, P < 0.01 and 0.6 0.8 vs 1.5 +/- 1.1, P < 0.01, respectively) were significantly improved. Compared with the control group, stool frequency was also significantly increased (3.5 +/- 1.5 v5 2.5 +/- 0.9, P < 0.01 and 4.1 +/- 1.7 v5 2.6 +/- 1.0, P < 0.01, respectively), and defecation condition (1.1 0.9 v5 1.6 +/- 1.1, P < 0.01 and 0.8 +/- 1.0 v5 1.6 +/- 1.1, P < 0.01, respectively) and stool consistency (1.0 0.8 v5 1.4 +/- 1.0, P < 0.05 and 0.6 +/- 0.8 v5 1.3 +/- 1.0, P < 0.01, respectively) significantly decreased after 1 and 2 wk of product consumption. During the same period, food intake did not change between the two groups, and safety parameters of the subjects were within normal ranges. CONCLUSION: This study suggests a beneficial effect of a fermented milk containing B. lactis DN-173010 on stool frequency, defecation condition and stool consistency in adult women with constipation constipated women after I and 2 wk of consumption. (C) 2008 The WJG Press. All rights reserved.
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