期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 14, 期 13, 页码 2065-2071出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.14.2065
关键词
extra-corporal liver therapy; prometheus; molecular adsorbent recirculation system; systemic hemodynamics
AIM: To evaluate treatment safety and hemodynamic changes during a single 6-h treatment with the Prometheus (TM) liver assist system in a randomized, controlled study. METHODS: Twenty-four patients were randomized to either the study group or to one of two control groups: Fractionated Plasma Separation Adsorption and Dialysis, Prometheus (TM) system (Study group; n = 8); Molecular Adsorbent Recirculation System (MARS)(TM) (Control group 1, n = 8); or hemodialysis (Control group 2; n = 8). All patients included in the study had decompensated cirrhosis at the time of the inclusion into the study. Circulatory changes were monitored with a Swan-Ganz catheter and bilirubin and creatinine were monitored as measures of protein-bound and water-soluble toxins. RESULTS: Systemic hemodynamics did not differ between treatment and control groups apart from an increase in arterial pressure in the MARS group (P = 0.008). No adverse effects were observed in any of the groups. Creatinine levels significantly decreased in the MARS group (P = 0.03) and hemodialysis group (P = 0.04). Platelet count deceased in the Prometheus group (P = 0.04). CONCLUSION: Extra-corporal liver support with Prometheus is proven to be safe in patients with end-stage liver disease but does not exert the beneficial effects on arterial pressure as seen in the MARS group. (c) 2008 WJG. All rights reserved.
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