期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 15, 期 4, 页码 346-352出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/15622975.2014.903336
关键词
DT-MRI; prenatal stress; neuroimaging; uncinate fasciculus; white matter
类别
资金
- March of Dimes foundation
- Baily Thomas Charitable Fund
- Academy of Medical Sciences
- NIHR Biomedical Research Centre for Mental Health at King's College London
- Institute of Psychiatry
- South London & Maudsley NHS Foundation Trust
Objectives. Maternal prenatal stress is associated with elevated risk of adverse behavioural outcomes in offspring. This association may involve developmental disruption to limbic-prefrontal white matter circuitry, of which the uncinate fasciculus is the major tract. One potential candidate for modulating brain development is maternal prenatal stress. We provide the first prospective study of prenatal stress and white matter microstructure in children. Methods. A total of 22 healthy children (mean age 7 years) of mothers recruited in pregnancy underwent diffusion tensor magnetic resonance imaging. We examined correlations between prenatal stressful life events and white matter microstructural organisation indices (fractional anisotropy (FA) and perpendicular diffusivity (D-perp)) of the uncinate fasciculus and a control tract. Results. Maternal prenatal stressful life events were correlated positively with right uncinate fasciculus FA, and negatively with right uncinate fasciculus D-perp in their child, with a similar trend with left uncinate fasciculus D-perp. Prenatal stress was not associated with control tract properties; sociodemographic/obstetric variables were not associated with FA/D-perp of either tract. Conclusions. Variation in maternal prenatal stress may be associated with differences in the development of white matter within brain networks underlying child social behaviour.
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