期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 16, 期 2, 页码 135-138出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/15622975.2014.952775
关键词
brain-derived neurotrophic factor; depression; deep brain stimulation; subcallosal cingulate region; biomarker
类别
资金
- Hotchkiss Brain Institute (HBI) Clinical Research Unit
- University of Calgary
- Alberta Innovates Health Solutions
- Alberta Innovates [201200847] Funding Source: researchfish
Objectives. Subcallosal cingulate (SCC) deep brain stimulation (DBS) is a promising experimental treatment for treatment-resistant depression (TRD). Given the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity and antidepressant efficacy, we examined the effect of SCC-DBS on serum BDNF in TRD. Methods. Four patients with TRD underwent SCC-DBS treatment. Following a double-blind stimulus optimization phase of 3 months, patients received continuous stimulation in an open label fashion for 6 months. Clinical improvement in depressive symptoms was evaluated bi-weekly for 6 months using the Hamilton Depression Rating Scale (HDRS). Mature serum BDNF levels were measured before and 9-12 months after surgery. Results. Three patients responded to SCC-DBS: two showed full clinical response (50% reduction in HDRS scores) and one had partial response (35% reduction in HDRS scores) at the clinical endpoint. Interestingly, all four patients showed reduction in serum BDNF concentration from pre-DBS baseline. Conclusions. SCC-DBS for TRD may be associated with decreased levels of serum BDNF. Longitudinal studies with multiple measurements in a larger sample are required to determine the role of BDNF as a biomarker of SCC-DBS antidepressant efficacy.
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