相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Targeting of the prostacyclin specific IP1 receptor in lungs with molecular conjugates comprising prostaglandin I2 analogues
Johannes Geiger et al.
BIOMATERIALS (2010)
Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy
Kevin Buyens et al.
JOURNAL OF CONTROLLED RELEASE (2010)
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis et al.
NATURE (2010)
Ligand-Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues
Mini Thomas et al.
OLIGONUCLEOTIDE THERAPEUTICS (2009)
Targeted Gene Delivery Mediated by Folate-polyethylenimine-block-poly(ethylene glycol) with Receptor Selectivity
Han Cheng et al.
BIOCONJUGATE CHEMISTRY (2009)
Hydrophobically Modified Oligoethylenimines as Highly Efficient Transfection Agents for siRNA Delivery
Alexander Philipp et al.
BIOCONJUGATE CHEMISTRY (2009)
Solid-Phase Synthesis of Oligonucleotide Conjugates Useful for Delivery and Targeting of Potential Nucleic Acid Therapeutics
Harri Lonnberg
BIOCONJUGATE CHEMISTRY (2009)
Enhanced Cytoplasmic Delivery of siRNA Using a Stabilized Polyion Complex Based on PEGylated Nanogels with a Cross-Linked Polyamine Structure
Atsushi Tamura et al.
BIOMACROMOLECULES (2009)
Efficient Delivery of Bcl-2-Targeted siRNA Using Cationic Polymer Nanoparticles: Downregulating mRNA Expression Level and Sensitizing Cancer Cells to Anticancer Drug
Cyrus W. Beh et al.
BIOMACROMOLECULES (2009)
Overcoming obstacles to develop effective and safe siRNA therapeutics
Leiming Li et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2009)
Targeting of the β2-adrenoceptor increases nonviral gene delivery to pulmonary epithelial cells in vitro and lungs in vivo
Markus Elfinger et al.
JOURNAL OF CONTROLLED RELEASE (2009)
A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery
Xu-Li Wang et al.
JOURNAL OF CONTROLLED RELEASE (2009)
Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery
Oleh Taratula et al.
JOURNAL OF CONTROLLED RELEASE (2009)
Treatment of disseminated ovarian cancer using nonviral interleukin-12 gene therapy delivered intraperitoneally
Jason G. Fewell et al.
JOURNAL OF GENE MEDICINE (2009)
Intranuclear fluorescence resonance energy transfer analysis of plasmid DNA decondensation from nonviral gene carriers
Yu Matsumoto et al.
JOURNAL OF GENE MEDICINE (2009)
Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate
Martin Meyer et al.
MOLECULAR PHARMACEUTICS (2009)
The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic
Mark E. Davis
MOLECULAR PHARMACEUTICS (2009)
Targeted Systemic Delivery of a Therapeutic siRNA with a Multifunctional Carrier Controls Tumor Proliferation in Mice
Xu-Li Wang et al.
MOLECULAR PHARMACEUTICS (2009)
The promises and pitfalls of RNA-interference-based therapeutics
Daniela Castanotto et al.
NATURE (2009)
Locked nucleic acid as a novel class of therapeutic agents
Rakesh N. Veedu et al.
RNA BIOLOGY (2009)
DNA condensation by PAMAM dendrimers:: Self-assembly characteristics and effect on transcription
Kristina Fant et al.
BIOCHEMISTRY (2008)
Acetal linked oligoethylenimines for use as pH-sensitive gene carriers
Veronika Knorr et al.
BIOCONJUGATE CHEMISTRY (2008)
Extracellular barriers to in Vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver
Rob S. Burke et al.
BIOCONJUGATE CHEMISTRY (2008)
Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity
Arkadi Zintchenko et al.
BIOCONJUGATE CHEMISTRY (2008)
A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery
Xu-Li Wang et al.
BIOMATERIALS (2008)
Self-Assembling Polyethylenimine Derivatives Mediate Efficient siRNA Delivery in Mammalian Cells
Gaelle Creusat et al.
CHEMBIOCHEM (2008)
Tailor-made poly(amidoamine)s for controlled complexation and condensation of DNA
Laura Hartmann et al.
CHEMISTRY-A EUROPEAN JOURNAL (2008)
Extracellular Targeting of Synthetic Therapeutic Nucleic Acid Formulations
Alexander Philipp et al.
CURRENT GENE THERAPY (2008)
Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding
Carolin Fella et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Gene therapy progress and prospects: synthetic polymer-based systems
D. Schaffert et al.
GENE THERAPY (2008)
Poly(ethylene glycol)-block-polyethylenimine copolymers as carriers for gene delivery:: Effects of PEG molecular weight and PEGylation degree
Xuan Zhang et al.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2008)
Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles
Samuel K. Lai et al.
JOURNAL OF CONTROLLED RELEASE (2008)
Bioreducible poly(amido amine)s with oligoamine side chains: Synthesis, characterization, and structural effects on gene delivery
Chao Lin et al.
JOURNAL OF CONTROLLED RELEASE (2008)
Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes
Debra T. Auguste et al.
JOURNAL OF CONTROLLED RELEASE (2008)
A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum
Kevin Buyens et al.
JOURNAL OF CONTROLLED RELEASE (2008)
PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacy
Anastasia Malek et al.
JOURNAL OF DRUG TARGETING (2008)
Breathing life into polycations: Functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery
Martin Meyer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum Dot-FRET
Hunter H. Chen et al.
MOLECULAR THERAPY (2008)
Cell surface nucleolin serves as receptor for DNA nanoparticles composed of pegylated polylysine and DNA
Xuguang Chen et al.
MOLECULAR THERAPY (2008)
Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of Ran
Nicole Tietze et al.
OLIGONUCLEOTIDES (2008)
Chemical Modification of siRNAs for In Vivo Use
Mark A. Behlke
OLIGONUCLEOTIDES (2008)
An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity
Veronika Knorr et al.
PHARMACEUTICAL RESEARCH (2008)
A biodegradable pH-sensitive micelle system for targeting acidic solid tumors
Vijay A. Sethuraman et al.
PHARMACEUTICAL RESEARCH (2008)
Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells
Margit Hornof et al.
JOURNAL OF GENE MEDICINE (2008)
Novel degradable oligoethylenimine acrylate ester-based pseudodendrimers for in vitro and in vivo gene transfer
V. Russ et al.
GENE THERAPY (2008)
Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo
Michael Neu et al.
JOURNAL OF CONTROLLED RELEASE (2007)
Sticky overhangs enhance siRNA-mediated gene silencing
Anne-Laure Bolcato-Bellemin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Deciphering the role of hydrogen bonding in enhancing pDNA-Polycation interactions
Lisa E. Prevette et al.
LANGMUIR (2007)
A dimethytmateic acid - metittin-potytysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential
Martin Meyer et al.
JOURNAL OF GENE MEDICINE (2007)
Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes
David B. Rozema et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Rapid optimization of gene delivery by parallel end-modification of poly(β-amino ester)s
Gregory T. Zugates et al.
MOLECULAR THERAPY (2007)
An acetal-based PEGylation reagent for pH-Sensitive shielding of DNA polyplexes
Veronika Knorr et al.
BIOCONJUGATE CHEMISTRY (2007)
Cellular dynamics of EGF receptor-targeted synthetic viruses
Karla de Bruin et al.
MOLECULAR THERAPY (2007)
Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
Jeremy D. Heidel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Reducible poly(amido ethylenimine) directed to enhance RNA interference
Ji Hoon Jeong et al.
BIOMATERIALS (2007)
Vectors for airway gene delivery
Pamela B. Davis et al.
AAPS JOURNAL (2007)
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
H. Hatakeyama et al.
GENE THERAPY (2007)
Interaction of polyamine gene vectors with RNA leads to the dissociation of plasmid DNA-carrier complexes
Stephanie Huth et al.
JOURNAL OF GENE MEDICINE (2006)
PEG conjugated VEGF siRNA for anti-angiogenic gene therapy
Sun Hwa Kim et al.
JOURNAL OF CONTROLLED RELEASE (2006)
Gene carriers based on hexanediol diacrylate linked oligoethylenimine: Effect of chemical structure of polymer on biological properties
Julia Kloeckner et al.
BIOCONJUGATE CHEMISTRY (2006)
Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro
Amy C. Richards Grayson et al.
PHARMACEUTICAL RESEARCH (2006)
Gene transfer with poly-melittin peptides
Chang-Po Chen et al.
BIOCONJUGATE CHEMISTRY (2006)
Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes
Sabine Boeckle et al.
JOURNAL OF CONTROLLED RELEASE (2006)
pH-responsive sulfonamide/PEI system for tumor specific gene delivery: An in vitro study
VA Sethuraman et al.
BIOMACROMOLECULES (2006)
PAMAM dendrimers for efficient siRNA delivery and potent gene silencing
Jiehua Zhou et al.
CHEMICAL COMMUNICATIONS (2006)
Optimizing targeted gene delivery: Chemical modification of viral vectors and synthesis of artificial virus vector systems
Sabine Boeckle et al.
AAPS JOURNAL (2006)
Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics
ZH Li et al.
FASEB JOURNAL (2005)
Dilution of reporter gene with stuffer DNA does not alter the transfection efficiency of polyethylenimines
A Kichler et al.
JOURNAL OF GENE MEDICINE (2005)
C- versus N-terminally linked metittin-polyethylenimine conjugates: the site of linkage strongly influences activity of DNA potyplexes
S Boeckle et al.
JOURNAL OF GENE MEDICINE (2005)
Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
S Hu-Lieskovan et al.
CANCER RESEARCH (2005)
Intracellular routing of plasmid DNA during non-viral gene transfer
D Lechardeur et al.
ADVANCED DRUG DELIVERY REVIEWS (2005)
Toward synthetic viruses:: Endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
GF Walker et al.
MOLECULAR THERAPY (2005)
Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile ß-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells
M Oishi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction
RC Carlisle et al.
JOURNAL OF GENE MEDICINE (2004)
Physicochemical and biological characterization of polyethylenimine-graft-poly(ethylene glycol) block copolymers as a delivery system for oligonucleotides and ribozymes
C Brus et al.
BIOCONJUGATE CHEMISTRY (2004)
In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine
K Itaka et al.
JOURNAL OF GENE MEDICINE (2004)
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
RM Schiffelers et al.
NUCLEIC ACIDS RESEARCH (2004)
Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer
S Boeckle et al.
JOURNAL OF GENE MEDICINE (2004)
A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs
V Bulmus et al.
JOURNAL OF CONTROLLED RELEASE (2003)
Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
ND Sonawane et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery
NC Bellocq et al.
BIOCONJUGATE CHEMISTRY (2003)
A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery
ML Forrest et al.
BIOCONJUGATE CHEMISTRY (2003)
Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides
N Murthy et al.
JOURNAL OF CONTROLLED RELEASE (2003)
Vectors based on reducible polycations facilitate intracellular release of nucleic acids
ML Read et al.
JOURNAL OF GENE MEDICINE (2003)
Endosomolysis by masking of a membrane-active agent (EMMA) for cytoplasmic release of macromolecules
DB Rozema et al.
BIOCONJUGATE CHEMISTRY (2003)
Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer
M Kursa et al.
BIOCONJUGATE CHEMISTRY (2003)
Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential
G Saito et al.
GENE THERAPY (2003)
Tumor-targeted gene delivery of tumor necrosis factor-α induces tumor necrosis and tumor regression without systemic toxicity
R Kircheis et al.
CANCER GENE THERAPY (2002)
Laterally stabilized complexes of DNA with linear reducible polycations: Strategy for triggered intracellular activation of DNA delivery vectors
D Oupicky et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
SM Elbashir et al.
NATURE (2001)
Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application
R Kircheis et al.
GENE THERAPY (2001)
A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression
KD Fisher et al.
GENE THERAPY (2000)
Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery
D Finsinger et al.
GENE THERAPY (2000)
Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system
M Nishikawa et al.
GENE THERAPY (2000)
Size-dependent DNA mobility in cytoplasm and nucleus
GL Lukacs et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)