期刊
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
卷 2, 期 4, 页码 431-440出版社
WILEY
DOI: 10.1002/wnan.87
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资金
- NCI NIH HHS [U54 CA119342, P50 CA116201] Funding Source: Medline
- NEI NIH HHS [R21 EY018914] Funding Source: Medline
- NIAMS NIH HHS [R01 AR056223] Funding Source: Medline
Fluorine (F-19) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton (H-1) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated F-19-containing compounds in vivo. Additionally, the MR spectra of F-19-containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin-lattice relaxation rate R-1) and the absolute quantity of molecule can be determined with F-19 MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative F-19 MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells. (C) 2010 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2010 2 431-440
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