期刊
FRONTIERS IN MICROBIOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2015.01322
关键词
invasive fungal infections; immunocompromised; immune regulation; immune enhancement; cytokines
类别
资金
- Clinician Scientist Award (CSA)
- Individual Research Grant (IRG)
- Bedside & Bench (BB) Grant
- Training Fellowship Award from the National Medical Research Council (NMRC), Singapore
- National University Health System, Singapore
- Pfizer
- Merck Sharp
- Dohme (MSD)
- Gilead
- Astellas
- Clinician Scientist Individual Research Grant - New Investigator Grant (CSIRG-NIG) from NMRC Singapore
A major global concern is the emergence and spread of systemic life-threatening fungal infections in critically ill patients. The increase in invasive fungal infections, caused most commonly by Candida and Aspergillus species, occurs in patients with impaired defenses due to a number of reasons such as underlying disease, the use of chemotherapeutic and immunosuppressive agents, broad-spectrum antibiotics, prosthetic devices and grafts, burns, neutropenia and HIV infection. The high morbidity and mortality associated with these infections is compounded by the limited therapeutic options and the emergence of drug resistant fungi. Hence, creative approaches to bridge the significant gap in antifungal drug development needs to be explored. Here, we review the potential anti fungal targets for patient-centered therapies and immune-enhancing strategies for the prevention and treatment of invasive fungal diseases.
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