4.6 Article

Recent advances toward a molecular mechanism of efflux pump inhibition

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biotechnology & Applied Microbiology

Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter

Robert Schulz et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Microbiology

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

Timothy J. Opperman et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Article Biochemistry & Molecular Biology

β-Lactam Selectivity of Multidrug Transporters AcrB and AcrD Resides in the Proximal Binding Pocket

Naoki Kobayashi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Structure of the AcrAB-TolC multidrug efflux pump

Dijun Du et al.

NATURE (2014)

Article Mathematical & Computational Biology

Efflux Pump-Mediated Antibiotics Resistance: Insights from Computational Structural Biology

Nadine Fischer et al.

INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES (2014)

Article Biochemistry & Molecular Biology

Porter domain opening and closing motions in the multi-drug efflux transporter AcrB

Nadine Fischer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)

Review Chemistry, Medicinal

RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms

Paolo Ruggerone et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)

Article Chemistry, Multidisciplinary

Drug Uptake Pathways of Multidrug Transporter AcrB Studied by Molecular Simulations and Site-Directed Mutagenesis Experiments

Xin-Qiu Yao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Multidisciplinary Sciences

Structural basis for the inhibition of bacterial multidrug exporters

Ryosuke Nakashima et al.

NATURE (2013)

Review Biochemistry & Molecular Biology

MOLECULAR DYNAMICS COMPUTER SIMULATIONS OF MULTIDRUG RND EFFLUX PUMPS

Paolo Ruggerone et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2013)

Article Chemistry, Multidisciplinary

Recognition of Imipenem and Meropenem by the RND-Transporter MexB Studied by Computer Simulations

Francesca Collu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

Attilio V. Vargiu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

Errett C. Hobbs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Thomas Eicher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Microbiology

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

Hiroshi Nikaido et al.

FEMS MICROBIOLOGY REVIEWS (2012)

Review Biology

Molecular dynamics simulations and drug discovery

Jacob D. Durrant et al.

BMC BIOLOGY (2011)

Article Chemistry, Physical

Role of Water during the Extrusion of Substrates by the Efflux Transporter AcrB

Robert Schulz et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2011)

Article Chemistry, Multidisciplinary

Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations

Attilio V. Vargiu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Multidisciplinary Sciences

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

Ryosuke Nakashima et al.

NATURE (2011)

Article Multidisciplinary Sciences

Complete reconstruction of an enzyme-inhibitor binding process by molecular dynamics simulations

Ignasi Buch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

Three ways in, one way out: Water dynamics in the trans-membrane domains of the inner membrane translocase AcrB

Nadine Fischer et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2011)

Article Microbiology

Kinetic Parameters of Efflux of Penicillins by the Multidrug Efflux Transporter AcrAB-TolC of Escherichia coli

Siew Ping Lim et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Article Biochemistry & Molecular Biology

Substrate path in the AcrB multidrug efflux pump of Escherichia coli

Fasahath Husain et al.

MOLECULAR MICROBIOLOGY (2010)

Article Multidisciplinary Sciences

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

Yumiko Takatsuka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations

Xin-Qiu Yao et al.

NATURE COMMUNICATIONS (2010)

Article Biochemical Research Methods

Functional Rotation of the Transporter AcrB: Insights into Drug Extrusion from Simulations

Robert Schulz et al.

PLOS COMPUTATIONAL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Drug transport mechanism of the AcrB efflux pump

Klaas M. Pos

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)

Article Biochemistry & Molecular Biology

Structural and functional aspects of the multidrug efflux pump AcrB

Thomas Eicher et al.

BIOLOGICAL CHEMISTRY (2009)

Review Microbiology

Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update

Jessica M. A. Blair et al.

CURRENT OPINION IN MICROBIOLOGY (2009)

Article Biochemistry & Molecular Biology

A Promiscuous Conformational Switch in the Secondary Multidrug Transporter MdfA

Nir Fluman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa

Gaby Sennhauser et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

Keiji Nagano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biotechnology & Applied Microbiology

Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation

Malin Kvist et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)

Article Biochemistry & Molecular Biology

Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB

Markus A. Seeger et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

Gaby Sennhauser et al.

PLOS BIOLOGY (2007)

Article Biochemical Research Methods

Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins

Lan Guan et al.

NATURE PROTOCOLS (2007)

Article Biochemistry & Molecular Biology

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa.: Part 6:: Exploration of aromatic substituents

Ken-ichi Yoshida et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism

Satoshi Murakami et al.

NATURE (2006)

Article Multidisciplinary Sciences

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism

Markus A. Seeger et al.

SCIENCE (2006)

Review Pharmacology & Pharmacy

Practical applications and feasibility of efflux pump inhibitors in the clinic - A vision for applied use

O Lomovskaya et al.

BIOCHEMICAL PHARMACOLOGY (2006)

Article Biochemistry & Molecular Biology

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa.: Part 5:: Carbon-substituted analogues at the C-2 position

K Yoshida et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium

K Nishino et al.

MOLECULAR MICROBIOLOGY (2006)

Article Biochemistry & Molecular Biology

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein

TW Loo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Crystal structure of bacterial multidrug efflux transporter AcrB

S Murakami et al.

NATURE (2002)

Review Biochemistry & Molecular Biology

Molecular dynamics simulations of biomolecules

M Karplus et al.

NATURE STRUCTURAL BIOLOGY (2002)

Article Chemistry, Medicinal

Peptidomimetics of efflux pump inhibitors potentiate the activity of levofloxacin in Pseudomonas aeruginosa

TE Renau et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)