期刊
AUTISM RESEARCH
卷 9, 期 1, 页码 17-32出版社
WILEY
DOI: 10.1002/aur.1530
关键词
BTBR; animal model; MSC; BDNF; neurogenesis
资金
- National Institute for Psychobiology in Israel
- Nella and Leon Benoziyo Center
- Joan and Jonathan Birnbach foundation
Autism spectrum disorders (ASD) are characterized by social communication deficits, cognitive rigidity, and repetitive stereotyped behaviors. Mesenchymal stem cells (MSC) have a paracrine regenerative effect, and were speculated to be a potential therapy for ASD. The BTBR inbred mouse strain is a commonly used model of ASD as it demonstrates robust behavioral deficits consistent with the diagnostic criteria for ASD. BTBR mice also exhibit decreased brain-derived neurotrophic factor (BDNF) signaling and reduced hippocampal neurogenesis. In the current study, we evaluated the behavioral and molecular effects of intracerebroventricularMSC transplantation in BTBR mice. Transplantation of MSC resulted in a reduction of stereotypical behaviors, a decrease in cognitive rigidity and an improvement in social behavior. Tissue analysis revealed elevated BDNF protein levels in the hippocampus accompanied by increased hippocampal neurogenesis in the MSC-transplanted mice compared with sham treated mice. This might indicate a possible mechanism underpinning the behavioral improvement. Our study suggests a novel therapeutic approach which may be translatable to ASD patients in the future. Autism Res2015. (c) 2015 International Society for Autism Research, Wiley Periodicals, Inc.
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