期刊
VOX SANGUINIS
卷 99, 期 3, 页码 267-273出版社
WILEY
DOI: 10.1111/j.1423-0410.2010.01341.x
关键词
adverse reactions; apheresis; cryopreservation; infusion
类别
Background and Objectives The infusion of thawed haematopoietic progenitor cells from apheresis (HPC-A) is associated with minor but frequent adverse reactions (ARs), which has been mainly attributed to dimethyl sulphoxide (DMSO). Nevertheless, other factors may play a role in the pathogenesis of such toxicity. Materials and Methods The ARs on a cohort of 423 cryopreserved HPC-A infusions for 398 patients in HPC transplantation program were analysed. Results ARs were reported in 105 graft infusions (24 center dot 8%) and most of them were graded as mild to moderate. The most frequently reported ARs were gastrointestinal and respiratory, and three patients presented epileptic seizure. The volume of DMSO/kg (P < 0 center dot 001), volume of red-blood-cells/kg (P = 0 center dot 02), number of nuclear cells (NCs)/kg (P < 0 center dot 001) and number of granulocytes/kg (P < 0 center dot 001) in the infused graft were significant in the univariate analysis for the occurrence of ARs. The amount of granulocytes/kg remained significant in the multivariate analysis (P < 0 center dot 001). The grade of ARs also correlated with the amount of cryopreserved granulocytes. Conclusion The incidence and grade of ARs during infusion of cryopreserved HPC-A are related to the amount of granulocytes in the graft.
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