期刊
VISION RESEARCH
卷 50, 期 7, 页码 652-664出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2009.08.018
关键词
Age-related Macular Degeneration; Cigarette smoking; Nrf2; Oxidative stress; Retinal pigmented epithelium
资金
- NCI NIH HHS [P30 CA023108, CA-78814, R01 CA078814] Funding Source: Medline
- NEI NIH HHS [EY019904, R01 EY014005, R01 EY019904] Funding Source: Medline
- NHLBI NIH HHS [P50HL084945, R01 HL081205, P50 HL084945, HL081205] Funding Source: Medline
Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response. (C) 2009 Elsevier Ltd. All rights reserved.
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