期刊
VISION RESEARCH
卷 50, 期 21, 页码 2176-2187出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2010.08.014
关键词
Electroretinogram (ERG); Scotopic threshold response (STR); Optic nerve transection (ONT); Axotomy; Retinal ganglion cells (RGCs); Adult albino and pigmented mice; Neuronal degeneration; Retina
资金
- Regional Government of Murcia
- Fundacion Seneca [05703/PI/07, 04446/GERM/07]
- Spanish Ministry of Education and Science [SAF-2009-10385, SAF2007-66175]
- Spanish Ministry of Health ISCIII [PIO06/0780, RD07/0062/0001, RD07/0062/0008, PIO70225]
Optic nerve transection (ONT) triggers retinal ganglion cell (RGC) death. By using this paradigm, we have analyzed for the first time in adult albino and pigmented mice, the effects of ONT in the scotopic threshold response (STR) components (negative and positive) of the full-field electroretinogram. Two weeks after ONT, when in pigmented mice approximately 18% of the RGC population survive, the STR-implicit time decreased and the p and nSTR waves diminished approximately to 40% or 55%, in albino or pigmented, respectively, with respect to the values recorded from the non-operated contralateral eyes. These changes were maintained up to 12 weeks post-ONT, demonstrating that the ERG-SIR is a useful parameter to monitor RGC functionality in adult mice. (C) 2010 Elsevier Ltd. All rights reserved.
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