期刊
VISION RESEARCH
卷 48, 期 13, 页码 1471-1478出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.visres.2008.03.019
关键词
fragile X syndrome; contrast detection; second-order; motion; threshold; forced-choice preferential looking
资金
- NEI NIH HHS [R01 EY018216, R01 EY018216-02] Funding Source: Medline
- NICHD NIH HHS [R01 HD036071, R01 HD036071-08, R01 HD056031, R01 HD056031-02, HD02274, HD36071, R01 HD056031-01, P30 HD002274] Funding Source: Medline
Studies have reported that a selective deficit in visual motion processing is present in certain developmental disorders, including Williams syndrome and autism. More recent evidence suggests a visual motion impairment is also present in adults with fragile X syndrome (FXS), the most common form of inherited mental retardation. The goal of the current study was to examine low-level cortical visual processing in infants diagnosed with FXS in order to explore the developmental origin of this putative deficit. We measured contrast detection of first-order (luminance-defined) and second-order (contra st-cle fined) gratings at two levels of temporal frequency, 0 Hz (static) and 4 Hz (moving). Results indicate that infants with FXS display significantly higher detection thresholds only for the second-order, moving stimuli compared to mental age-matched typically developing controls. (c) 2008 Elsevier Ltd. All rights reserved.
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