期刊
FRONTIERS IN MICROBIOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fmicb.2015.00068
关键词
aflatoxin; deoxynivalenol; mycotoxin; non-ribosomal peptide; polyketide; penicillin; terpene
类别
资金
- Agriculture and Food Research Initiative Competitive Grant from the USDA National Institute of Food and Agriculture [2014-67013-21561]
- Guillermo Marques at the University of Minnesota-University Imaging Centers
- NIFA [687406, 2014-67013-21561] Funding Source: Federal RePORTER
Fungal secondary metabolism is often considered apart from the essential housekeeping functions of the cell. However, there are clear links between fundamental cellular metabolism and the biochemical pathways leading to secondary metabolite synthesis. Besides utilizing key biochemical precursors shared with the most essential processes of the cell (e.g., amino acids, acetyl CoA, NADPH), enzymes for secondary metabolite synthesis are compartmentalized at conserved subcellular sites that position pathway enzymes to use these common biochemical precursors. Co-compartmentalization of secondary metabolism pathway enzymes also may function to channel precursors, promote pathway efficiency and sequester pathway intermediates and products from the rest of the cell. In this review we discuss the compartmentalization of three well-studied fungal secondary metabolite biosynthetic pathways for penicillin G, aflatoxin and deoxynivalenol, and summarize evidence used to infersubcellular localization. We also discuss how these metabolites potentially are trafficked within the cell and may be exported.
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