4.5 Article

Toll-like receptor (TLR)4 signalling induces myeloid differentiation primary response gene (MYD) 88 independent pathway in avian species leading to type I interferon production and antiviral response

期刊

VIRUS RESEARCH
卷 256, 期 -, 页码 107-116

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2018.08.008

关键词

Toll-like receptor 4; Lipopolysaccharide; Myeloid differentiation primary response gene; 88 independent pathway; Avian macrophage; Type I interferon; Nitric oxide

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资金

  1. Canadian Poultry Research Council [AMN048]
  2. Alberta Livestock and Meat Agency [2011R037R]
  3. Agriculture and Agri Food Canada
  4. Egyptian government

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Engagement of toll-like receptor (TLR)4 ligand, lipopolysaccharide (LPS) with TLR4 in mammals activates two downstream intracellular signaling routes; the myeloid differentiation primary response gene (MyD)88 dependent and independent pathways. However, existence of the later pathway leading to production of type I interferons (IFNs) in avian species has been debated due to conflicting observations. The objective of our study was to investigate whether LPS induces type I IFN production in chicken macrophages leading to antiviral response attributable to type I IFN. We found that LPS elicits type I IFN response dominated by IFN-beta production. We also found that reduction in infectious laryngotracheitis virus (ILTV) replication by LPS-mediated antiviral response is attributable to type I IFNs in addition to nitric oxide (NO). Our findings imply that LPS elicits both MyD88 dependent and independent pathways in chicken macrophages consequently eliciting anti-ILTV response attributable to production of both type I IFNs and NO.

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