期刊
VIRUS RESEARCH
卷 192, 期 -, 页码 92-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2014.08.015
关键词
Human immunodeficiency virus; Conserved oligomeric Golgi complex; Trans-Golgi network; HIV-dependency factors
类别
资金
- National Institutes of Health (NIH) [1R33AI088601]
- Miami Center for AIDS Research (CFAR) at the University of Miami Miller School of Medicine - National Institutes of Health [P30AI073961]
All viruses require host cell factors to replicate. A large number of host factors have been identified that participate at numerous points of the human immunodeficiency virus I (HIV-1) life cycle. Recent evidence supports a role for components of the trans-Golgi network (TGN) in mediating early steps in the HIV-1 life cycle. The conserved oligomeric Golgi (COG) complex is a heteroctamer complex that functions in coat protein complex I (COPI)-mediated intra-Golgi retrograde trafficking and plays an important role in the maintenance of Golgi structure and integrity as well as glycosylation enzyme homeostasis. The targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication. This inhibition of HIV-1 replication preceded late reverse transcription (RT) but did not affect viral fusion. Silencing of the COG interacting protein the t-SNARE syntaxin 5, showed a similar defect in late RT product formation, strengthening the role of the TGN in HIV replication. (C) 2014 Elsevier B.V. All rights reserved.
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