期刊
VIRUS RESEARCH
卷 178, 期 1, 页码 63-77出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2013.05.009
关键词
Virus evolution; Reservoir; Wild bird; Cade; Lineage
类别
资金
- American Lebanese Syrian Associated Charities (ALSAC)
- NIAID/NIH [HHSN266200700005C]
The ecology of highly pathogenic avian influenza (HPAI) H5N1 has significantly changed from sporadic outbreaks in terrestrial poultry to persistent circulation in terrestrial and aquatic poultry and potentially in wild waterfowl. A novel genotype of HPAI H5N1 arose in 1996 in Southern China and through ongoing mutation, reassortment, and natural selection, has diverged into distinct lineages and expanded into multiple reservoir hosts. The evolution of Goose/Guangdong-lineage highly pathogenic H5N1 viruses is ongoing: while stable interactions exist with some reservoir hosts, these viruses are continuing to evolve and adapt to others, and pose an un-calculable risk to sporadic hosts, including humans. (C) 2013 Elsevier B.V. All rights reserved.
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