期刊
VIRUS RESEARCH
卷 177, 期 1, 页码 11-21出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2013.07.004
关键词
EBV; Spermidine/spermine N-1-acetyltransferase; Polyamines; Burkitt's lymphoma; c-myc; Akata
类别
资金
- COBRE grant from National Institute of General Medical Sciences [GM103433]
- National Cancer Institute [CA-67372, CA-114416]
Transition of Akata Burkitt's lymphoma (BL) from a malignant to nonmalignant phenotype upon loss of Epstein Barr virus (EBV) is evidence for a viral contribution to tumorigenesis despite the tight restriction of EBV gene expression in BL Examination of global cellular gene expression in Akata subclones that retained or lost EBV identified spermidine/spermine N-1-acetyltransferase (SAT1), an inducible enzyme whose catabolism of polyamines affects both apoptosis and cell growth, as one of a limited number of cellular genes downregulated by EBV. Re-infection of the EBV-negative Akata clone reduced SAT1 mRNA to a level comparable with the parental EBV-positive Akata. EBV-positive Akata cells demonstrated decreased SAT1 enzyme activity concomitant with altered intracellular polyamine constituents. Reduction of SAT1 in EBV-positive BL was a transcriptional effect. Forced expression of the viral BCL2 homologue, BHRF1, in an EBV-negative Akata clone reduced SAT1 mRNA. Thus, EBV repression of polyamine catabolism becomes a complementary alteration to dysregulated c-myc enhancement of polyamine synthesis in BL and favorable to BL lymphomagenesis. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据