期刊
VIRUS RESEARCH
卷 157, 期 2, 页码 193-203出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2010.10.026
关键词
Human cytomegalovirus; Glioblastoma; Oncomodulation; Tumor promoter
类别
资金
- NINDS NIH HHS [R21 NS067395-02, R21 NS067395, R01 NS070289] Funding Source: Medline
Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes persistent infection in humans and can cause severe disease in fetuses and immunocompromised individuals. Although HCMV is not currently causally implicated in human cancer, emerging evidence suggests that HCMV infection and expression may be specifically associated with human malignancies including malignant glioma, colon, and prostate cancer. In addition, multiple investigators have demonstrated that HCMV can dysregulate signaling pathways involved in initiation and promotion of malignancy, including tumor suppressor, mitogenic signaling, inflammatory, immune regulation, angiogenesis and invasion, and epigenetic mechanisms. This review highlights some of the recent evidence that HCMV might play a role in modulating the tumor microenvironment as well as in the initiation and promotion of tumor cells themselves. (C) 2010 Elsevier B.V. All rights reserved.
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