4.5 Article

Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells

期刊

VIRUS RESEARCH
卷 160, 期 1-2, 页码 360-366

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2011.07.011

关键词

Respiratory virus; Human nasal epithelial cells; Interferon lambda

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资金

  1. Japan Society for the Promotion of Science
  2. Akiyama Life Science Foundation
  3. Grants-in-Aid for Scientific Research [23390398, 21591259] Funding Source: KAKEN

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As an innate immune response against diverse viral infections, a host induces two types of interferon (IFN), type-I (IFN-beta/alpha) and type-III (IFN-lambda). We investigated IFN inductions by respiratory viruses, including respiratory syncytial virus (RSV), measles virus and mumps virus in human nasal epithelial cells (NECs). IFN-lambda, but not IFN-beta/alpha, was induced by respiratory virus infection in primary NECs and immortalized NECs through transfection with the human telomerase reverse transcriptase gene (hTERT-NECs). In contrast, both IFN-lambda and IFN-beta/alpha were induced by RSV infection in human bronchiolar carcinoma cell line A549. Suppression of retinoic acid-inducible gene-I (RIG-I) expression using siRNA significantly reduced IFN-lambda 1 production in RSV-infected hTERT-NECs, while suppression of melanoma differentiation-associated gene 5 (MDA5) expression did not. Exogenous IFN-lambda 1 treatment suppressed RSV replication and chemokine induction in hTERT-NECs. These data indicate that IFN-lambda, but not IFN-beta/alpha, contributes to the main first line defense via RIG-I-dependent pathway against respiratory virus infection in NECs. (C) 2011 Elsevier B.V. All rights reserved.

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