期刊
VIRUS RESEARCH
卷 161, 期 1, 页码 47-58出版社
ELSEVIER
DOI: 10.1016/j.virusres.2011.02.011
关键词
HEV; ORF1; ORF2; ORF3; RNA replication
类别
资金
- Wellcome Trust, UK
- National Institutes of Health, USA
- Department of Biotechnology, India
- ICGEB internal resources
- Council for Scientific and Industrial Research, India
This review details the molecular virology of the hepatitis E virus (HEV). While replicons and in vitro infection systems have recently become available, a lot of information on HEV has been generated through comparisons with better-studied positive-strand RNA viruses and through subgenomic expression of viral open reading frames. These models are now being verified with replicon and infection systems. We provide here the current knowledge on the HEV genome and its constituent proteins - ORF1, ORF2 and ORF3. Based on the available information, we also modify the existing model of the HEV life cycle. (C) 2011 Elsevier B.V. All rights reserved.
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