期刊
VIRUS RESEARCH
卷 158, 期 1-2, 页码 161-168出版社
ELSEVIER
DOI: 10.1016/j.virusres.2011.03.027
关键词
Coronavirus; FIP; VEGF; Monocyte; Macrophage; Effusion
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology [22780285]
- School of Veterinary Medicine of Kitasato University [E0904]
- Kitasato University
- Grants-in-Aid for Scientific Research [22780285] Funding Source: KAKEN
Feline infectious peritonitis virus (FIPV) causes a fatal disease called FIP in Felidae. The effusion in body cavity is commonly associated with FIP. However, the exact mechanism of accumulation of effusion remains unclear. We investigated vascular endothelial growth factor (VEGF) to examine the relationship between VEGF levels and the amounts of effusion in cats with FIP. Furthermore, we examined VEGF production in FIPV-infected monocytes/macrophages, and we used feline vascular endothelial cells to examine vascular permeability induced by the culture supernatant of FIPV-infected macrophages. In cats with FIP, the production of effusion was related with increasing plasma VEGF levels. In FIPV-infected monocytes/macrophages, the production of VEGF was associated with proliferation of virus. Furthermore, the culture supernatant of FIPV-infected macrophages induced hyperpermeability of feline vascular endothelial cells. It was suggested that vascular permeability factors, including VEGF, produced by FIPV-infected monocytes/macrophages might increase the vascular permeability and the amounts of effusion in cats with FIP. (C) 2011 Elsevier B.V. All rights reserved.
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